CORRECT USE OF PROPAFENONE
Propafenone, particularly at high doses, can exert a negative inotropic effect on the myocardium. A clinical study(3) in patients without clinical signs of left ventricular dysfunction has shown a slight reduction in ejection fraction (LVEF from 52 ± 9% to 48 ± 11%). In a second group of patients with left ventricular dysfunction (baseline LVEF = 35 ± 8%), Propafenone, 600 mg/day given in conjunction with Digoxin, had no significant effect on the average ejection fraction (LVEF after Propafenone 36 ± 10%).
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