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Hereditary angioedema: Berinert to treat abdominal attacks, facial swelling

Endothelin receptor antagonists: Darusentan for treatment of resistant hypertension

Antiepilepsy drugs: Valproate linked to risk on cognitive function for unborn children

Diabetes mellitus of type 2: Januvia and Janumet linket to acute pancreatitis

Intelence linked to severe skin reactions

EU: withdrawal of the marketing authorisations for medicines containing Dextropropoxyphene

Saphris for treating schizophrenia and bipolar disorder: FDA has approved

Antipsychotic drugs: restrictions on use of Clozapine may have caused thousands of extra deaths worldwide in schizophrenia patients

Rheumatoid arthritis: Golimumab shows promising results in patients who have poor response to other TNF-alpha inhibitors

Rheumatoid arthritis: treatment with the monoclonal anti-TNF-alpha antibodies Adalimumab and Infliximab linked to increased risk for herpes zoster

Risk of tuberculosis: higher for patients receiving anti-TNF monoclonal antibody therapy than for those receiving soluble TNF receptor therapy

Lantus possibly increases cancer risk

TNF blockers linked to increased risk of lymphoma, leukaemia and new-onset psoriasis

Type II diabetes: pancreatic cancer risk decreased by Metformin, increased by Insulin or insulin secretagogues

Velaglucerase alfa for type 1 Gaucher disease: positive results from first of three phase III trials

FDA: early communication about safety of Lantus

Montelukast linked to suicidality and other psychiatric adverse reactions

Serious ocular adverse reactions linked to intravitreal injection of Triamcinolone acetonide

Boxed warning for smoking cessation drugs Chantix and Zyban: risk of serious mental health events

Multaq to maintain normal heart rhythm in patients with atrial fibrillation or atrial flutter: FDA approved

FDA: Alimta as first maintenance therapy for advanced lung cancer

Effient to reduce the risk of myocardial infarction in angioplasty: FDA approved

Javlor in metastatic treatment of bladder cancer after failure of a prior Platinum-containing regimen: positive CHMP opinion

VAERS reports: 28 deaths related to Gardasil in 2008

Eltrombopag reduces bleeding, and increases platelet levels in idiopathic thrombocytopenic purpura

Papillomavirus: syncope following vaccination with Gardasil

Multiple sclerosis: Natalizumab promotes remyelination

Gaucher disease: Genz-112638 meets primary endpoint in a Phase 2 clinical trial

Homozygous familial hypercholesterolemia: 25 percent LDL-C reduction with Mipomersen

Graves’ disease: Propylthiouracil linked to liver failure

Safety and efficacy of Sirolimus as an immunosuppressant have not been established in liver transplant patients

Neuropsychiatric events with leukotriene inhibitors: Montelukast, Zafirlukast and Zileuton

Avastin for treatment of glioblastoma multiforme

Hyponatremia: FDA has approved Samsca

Gastrointestinal perforation, skin lesions or ocular disorders associated with Tarceva

Secondary exposure to Testosterone gel

Inflammatory breast cancer: Lapatinib could be used to treat patients with aggressive form

Metastatic HER2+ breast cancer: a combination of Capecitabine, Vinorelbine, and Trastuzumab is promising option

Bevacizumab effective at delaying alkylator-refractory anaplastic oligodendroglioma progression

Anti-angiogenesis inhibitors may improve outcomes of patients with sex cord-stromal tumors

Rheumatoid arthritis: Anakinra, a modest benefit with some risk

Allergic reactions to Clopidogrel can be treated with steroids and antihistamines

Anti–TNF-alpha agents may be associated with increased risk for herpes zoster

Clopidogrel plus Aspirin reduces myocardial infarction risk in patients with acute coronary syndrome

Proton pump inhibitors interfere with Clopidogrel

Cladribine in patients with relapsing-remitting multiple sclerosis: two-year data

Ofatumumab: high response rates in patients with Fludarabine- and Alemtuzumab-refractory chronic lymphocytic leukemia

Antiepileptics associated with decreased bone mineral density

Methylthioninium in high intravenous doses should be avoided for patients being treated with serotonergic antidepressants

Ceftriaxone and Calcium-containing products may be used concomitantly in patients greater than 28 days of age

FDA has approved Simponi for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

Genentech: voluntary withdrawal of Raptiva from the U.S. market

A case of progressive multifocal leukoencephalopathy in a Raptiva patient

Sorafenib targets acute myeloid leukemia driven by mutant FLT3 gene

Sorafenib: older renal cancer patients appear to benefit from treatment

Genetic study sheds new light on lung adenocarcinoma

BRAF mutations in colorectal cancer cause resistance to anti-EGFR therapy

Cancer: new biomarkers can predict response to treatments

Everolimus prolongs progression-free survival in patients with metastatic kidney cancer who have failed on other treatments

Imatinib and Sunitinib prevent and reverse type 1 diabetes

Consolidation therapy following chemoimmunotherapy in B-cell chronic lymphocytic leukaemia: infection-related deaths reported with the use of MabCampath

FDA has approved Degarelix for patients with advanced prostate cancer

Suicidal behavior and ideation linked to antiepileptic drugs

DECREASE III trial: Fluvastatin XL is associated with improved cardiac outcome after major vascular surgery

Men who take Acetylsalicylic acid have significantly lower PSA levels

Acetylsalicylic acid does not prevent myocardial infarctions in patients with diabetes

Chlorthalidone reduces risk for a type of heart failure that is more common among women

Citalopram may prevent depression in patients with head and neck cancer

Catumaxomab well tolerated in treatment of gastric cancer

Multiple sclerosis: Rituximab shows promise

Patient with systemic mastocytosis responds to Imatinib

Risk of psychiatric side effects is approximately doubled in patients taking Acomplia

Bowel cleansing: oral Sodium Phosphate products associated with risk of acute kidney injury

Use of conventional antipsychotics in elderly patients with dementia

FDA has approved Toviaz to treat overactive bladder

FDA has approved Banzel to treat seizures associated with Lennox-Gastaut syndrome

Rituximab and Dexamethasone compared to Dexamethasone alone in idiopathic thrombocytopenic purpura

Chronic idiopathic thrombocytopenic purpura: long-term treatment with oral Eltrombopag

Rheumatoid arthritis: B cell depletion with anti-CD20

Influenza: safety information on Tamiflu

Dronedarone: benefit risk assessment

Human papillomavirus vaccine: Gardasil

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