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Role of gene mutations causing lupus in mice identified

Exenatide reduces blood glucose levels when added to patients using a thiazolidinedione

Rosuvastatin plus diet in hypercholesterolemic adults unable to tolerate other statins

Mechanism for neurodenegerative diseases linked to transport proteins

HBZ protein enhances the ability of HTLV-1 to establish a persistent infection

ACC/AHA/ESC 2006 Guidelines - Pharmacological rate control during atrial fibrillation

Exubera's long-term efficacy and safety in adults with type 1 or type 2 diabetes

Trans fat leads to weight gain even on same total calories

Inhibition of LDH-A may represent a rational and safe strategy for treatment of cancer

Peripheral neuropathic pain: Lyrica is not recommended for use within NHS Scotland

Metastatic colorectal cancer - NICE: insufficient evidence to recommend Avastin and Erbitux

HIV infection, Prezista, a new protease inhibitor for patients who do not respond to existing drugs, approved

Inhibition of TWEAK may provide a new approach to rheumatoid arthritis therapy

RUTH trial: Raloxifene linked to increased risk of venous thromboembolism and fatal stroke

Scyllo-inositol appears promising for Alzheimer's disease

More than one-third of disaster victims may suffer from stress disorder

Brain metastases: WBRT added to focused radiotherapy may reduce the likelihood of recurrences

Spirometry underused in patients with COPD

Community acquired pneumonia: effectiveness of discontinuing antibiotic treatment after 3 days versus 8 days

Imatinib attacks prostate cancer in mouse model by destroying its blood supply

Green tea: antioxidant protective effects of the polyphenolic EGCG

Increased sensitivity to nerve signals might offer a new approach to diabetes

Sibutramine linked to QT interval prolongation

Antidepressants don’t seem to be related to suicide attempts and death in adults

Acupuncture on stroke rehabilitation: no clear evidence

Incidence of hypertension reduced with early intervention

Alzheimer's disease: THC inhibits the enzyme acetylcholinesterase

Salmeterol can worsen asthma symptoms

Experts: concerns over the asthma drugs Salmeterol and Formoterol

Ankylosing spondylitis: Humira approved for reducing signs and symptoms

FDA has approved new use for Plavix: STEMI myocardial infarction

Epilepsy: Valproate linked to high risk for fetal death and birth defects

Potential benefits and risks of treatment with antidepressants during pregnancy

Combined use of triptans and antidepressants may result in life-threatening serotonin syndrome

Preoperative statin therapy linked to reduced cardiac mortality after CABG

Bacteria: H-NS protein recognizes foreign DNA and prevents it from becoming active

Elk-1, a transcription factor, may play a role in cell death and mitochondria-related diseases

First trimester of pregnancy: ACE inhibitors linked to increased risk of birth defects

Adolescents with negative body image concerns are more likely to be depressed, anxious, and suicidal

Some patients with cardiogenic shock survive years after aggressive treatment

Acomplia may be dangerous for women of reproductive age

Quetiapine as effective as Risperidone for treatment of schizophrenia

Sutent is a promising agent for treatment of metastatic renal cell cancer

Breast cancer: Raloxifene and Tamoxifen are both effective but have different side effects

Lung cancer: ICAM, a new predictor for treatment response and survival

Vitamin D and Calcium supplements have varied effects on breast cancer risk

Sunitinib shows promise in children with metastatic gastrointenstinal stromal tumor resistant to Imatinib

Lung cancer: radiation therapy shown to increase survival

Mutation in gene for PDE11A associated with development of micronodular adrenocortical hyperplasia

Sexual desire and migraine headache may be linked

A gene expression signature for Burkitt lymphoma identified

Rimonabant, a new drug for weight loss

Hedgehog signals linked to an increase in the density of blood vessels in the heart

Esomeprazole more effective than Lansoprazole in maintaining healing of erosive esophagitis

Sibutramine shouldn't be used in combination with SSRI antidepressants due to a possible risk of serotonin syndrome

Non-small cell lung cancer: disease control rate may be a more powerful predictor of survival than tumor shrinkage

Head and neck cancer: Docetaxel combined with standard chemotherapy reduces mortality by nearly 30 percent

Donepezil: no evidence to support the use for patients with mild cognitive impairment

Breathing exercises can cut inhaler use in mild asthma

The Cochrane Library: news alert, Issue 3 - 2006

Preterm or low birthweight infants at increased risk of hyperactivity disorder

Lack of sleep linked to increased risk of hypertension

Cancer cells may move via wave stimulation

Insulin is critical for blood vessel formation

The Cochrane Library: news alert, Issue 2 - 2006

Parkinson's: single mutated copy of parkin may lead to earlier symptom onset

Prostate cancer: PSA density, a new predictor of disease for overweight men

Gene therapy accelerates healing of damaged skeletal muscle

Advanced kidney cancer: Sunitinib shows significant benefits over Interferon-alpha

Breast-sparing surgery an option for women with breast cancer gene mutation

Preventive surgery reduces the risk of BRCA-associated breast and ovarian cancers

Association between hematopoietic stem cells and osteoblasts may be important to stem cell function

Coxsackievirus has evolved an indirect route of attack

Ebola virus infection: antisense drugs protect non-human primates from lethal disease

Many patients on diuretics have abnormal sodium and potassium levels

Complex infection fighting mechanism described, new light on autoimmune disorders

Different factors predispose to chronic fatigue syndrome

Obese adolescents: Sibutramine added to behavior therapy reduces BMI and body weight

Death in mammalian cells overloaded with saturated fat: role of EF1A-1 protein

Age-related macular degeneration may be linked to quality of dietary carbohydrates

Chronic myelogenous leukaemia: after five years on Gleevec overall survival reaches 89 percent

Dicer enzyme involved in RNA interference

CaR essential for localization of blood stem cells

Tool to silence genes in specific tissues using RNAi developed

miRNA signature in solid tumors identified

Genetically engineered muscle-derived stem cells can repair cartilage

Statins as potential modifiers of rheumatoid arthritis

Avian flu transmission to humans may be higher than thought

Depression: brain imaging can predict effectiveness of cognitive behavior therapy

12.5 kDa cystatin could be used to diagnose multiple sclerosis

Statin use linked to reduced risk of nuclear cataract

NICE and British Hypertension Society: updated clinical guideline on the management of hypertension

Hepatotoxicity with black cohosh

Interactions with macrolide antibiotics

Nerve damage in complex regional pain syndrome-I discovered

Soy: no evidence that isoflavones stimulate cell growth in breast tissue

Pregnancy: newer antidepressants linked to persistent pulmonary hypertension in newborns

Caffeine limits blood flow to heart muscle during exercise

Cryopyrin protein responds to invading bacteria by activating of IL-1beta

Hedgehog protein blocks fat production, produces more bone

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