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Metastatic colorectal cancer: better surgical interventions, new chemotherapeutic and biological agents increase 5-year survival from 8 to 30 percent

Biomarkers: Lp-PLA2 and hs-CRP improve ischemic stroke prediction

Pregnancy alone is not associated with increased risk for mental disorders

Vision therapy appears to improve visual function in macular disease

Modifiable factors associated with exceptionally long life

Corneal transplants: infection is an uncommon but serious complication

Multiple sclerosis: smoking Marijuana impairs cognitive function

HIV persists in the gut despite long-term HIV therapy

Migraine associated with lower risk of breast cancer

Higher risk of fractures in patients with heart failure

Fluoroquinolones as a cause of tendon disorders

Hyponatraemia associated with drugs

CYP3A4 inhibitors may increase potential for Colchicine toxicity

Small birth size linked to changes in the cardiovascular system that predispose to later disease

Coronary heart disease is linked to worse mental processes that predict the onset of dementia

Rituximab significantly reduces kidney injury in membranous nephropathy

Overactive bladder: FDA has approved Toviaz

Promising results in phase 1 gene therapy trial for Leber congenital amaurosis

Glucosamine and/or Chondroitin no better than placebo in slowing structural damage of knee osteoarthritis

Refractory status epilepticus: Propofol could be fatal

FDA: risks of life-threatening infections for psoriasis drug Raptiva

Regular Salmeterol for asthma: more evidence of long-term problems

Removing ovaries during hysterectomy: effects remain unknown

Oxygen therapy might ease pain of migraine, cluster headaches

St. John's wort relieves symptoms of major depression

Early breast cancer: LHRH agonists show promise

Eczema: there is no evidence probiotics can relieve the symptoms

Honey helps to heal wounds

Formoterol for asthma: evidence of serious adverse effects

MC-1 does not appear to reduce risk of myocardial infarction or death following CABG surgery

Invasive fungal infections associated with TNF-alpha inhibition

FDA has approved Seroquel XR for the treatment of bipolar depression and bipolar mania

Bisphenol A is linked to heart disease and diabetes in adults

Viread for chronic hepatitis B in adults

Statins do not increase the risk of amyotrophic lateral sclerosis

Acute ischemic stroke: more deaths in the group of patients who received Epoetin alfa

Treatment with RAD001 increases time without tumour growth in patients with advanced kidney cancer

Atorvastatin lower risk of stroke for elderly people

Stroke: Imatinib may reduce the risk of tPA-associated bleeding

FDA has approved Nplate for treatment of chronic immune thrombocytopenic purpura

FDA: TNF-alpha blockers associated with risk of fungal infections

Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia

FDA has approved Gamunex for treatment of inflammatory demyelinating polyneuropathy

Methadone breaks resistance in untreatable forms of leukemia

FDA has approved expanded uses for Gardasil to include preventing certain vulvar and vaginal tumors

TIME-CHF trial: intensified heart failure therapy does not improve survival free of all-cause hospitalisations in older patients

FDA to investigate possible Vytorin-cancer link

FDA has approved Xenazine for treatment of chorea in Huntington’s disease

Diabetes: cases of hemorrhagic or necrotizing pancreatitis associated with Byetta

Alcohol dependence: Naltrexone associated with severe injection site reactions

Lapatinib blocks the growth of breast cancer cells that spread to the brain in a mouse model

Vitamin C injections slow tumor growth in mouse models

Alzheimer's disease: novel therapeutic strategies

Aortic stenosis: Vytorin does not slow progression of aortic valve disease

Safety concerns with fluoroquinolones: increased risk of tendinitis and tendon rupture

Duloxetine: a review of safety reports

Serious skin reactions linked to TNF-alpha antagonists

Increased risk of death associated with off-label use of antipsychotic drugs to treat psicosis in older people with dementia

Insomnia: the effectiveness of Ramelteon has not been demonstrated for CHMP

Head and neck cancer: Cetuximab in combination with Docetaxel and Cisplatin as induction therapy

Trasylol: access limited to investigational use

Metformin increases pathologic complete response rates in breast cancer patients with diabetes

Antifibrinolytics: Aprotinin associated with increased risk of death

FDA has approved Entereg to help restore bowel function following surgery

Topiramate linked to angle-closure glaucoma

POISE trial: Metoprolol increases the risk of death and stroke around the time of non-cardiac surgery

Tuberculosis and infections with Enbrel

Evra: myocardial infarction and thromboembolic events

FDA: Cimzia to treat Crohn's disease approved

Intravenous immune globulin: myocardial infarction and cerebrovascular and thrombotic adverse reactions

FDA has approved Amitiza for irritable bowel syndrome with constipation

FDA has approved Relistor for opioid-induced constipation

Diabetes: Pioglitazone and Rosiglitazone may be related to fracture risk

Osteoporosis: Alendronate may be associated with atrial fibrillation

New genetic links to psoriasis uncovered

Quetiapine extended release in treatment of bipolar disorder

Antipsychotics: Olanzapine cause changes in metabolism earlier than expected

Anticholinergic drugs may increase cognitive decline in older people

Statins may help reduce blood pressure

Rosuvastatin can reduce plaques that cause myocardial infarction

Asthma: possible link between Singulair and suicide

Exubera linked to lung cancer

Neuropsychiatric events linked to Relenza

FDA has approved Rotarix, a new vaccine to prevent gastroenteritis caused by rotavirus

Smoking is greatest predictor of recurrent cardiac events among young myocardial infarction survivors

Asthma: possible association between Singulair and behavior/mood changes, suicidality and suicide

Sorafenib targets acute myeloid leukemia driven by mutant FLT3 gene

HIV-1 infection: Abacavir and Didanosine linked to increased risk of myocardial infarction

Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations

Regranex linked to an increased risk of tumor in patients with diabetes

Brain aneurysm: smokers treated with coils at higher risk of recurrence

Intracranial stent reduces arterial blockage in the short term

Progressive multifocal leukoencephalopathy in CellCept treated patients

Provigil associated with serious rash and psychiatric symptoms

Ductal carcinoma in situ: patients overestimate breast cancer risks

HPV-positive head and neck cancer patients have a better response and survival than HPV-negative patients

Additional changes to Ortho Evra, a birth control patch

Six infection-related deaths reported after treatment with MabCampath in patients with B-cell chronic lymphocytic leukemia

Tysabri to treat moderate-to-severe Crohn's disease: FDA has approved

Alpha-Linolenic acid in treatment for dry eye syndrome

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