Breast cancer, serious complications linked to Doxorubicin-Docetaxel regimen


A clinical trial demonstrated that the chemotherapy regimen of Doxorubicin plus Docetaxel ( Taxotere ), used to treat breast cancer, was associated with an increased risk of serious complications, resulting in the premature termination of the trial.

Combinations of certain breast cancer drug classes have proven superior to some single classes alone in advanced or metastatic breast cancer.
Uncertainties remain regarding the optimal schedule of administration of combination regimens, as well as safety and cost issues, and whether some drugs should be used outside of clinical trials.

Etienne G. C. Brain, of the René Huguenin Cancer Centre, Saint-Cloud, France and colleagues describe the adverse events associated with the chemotherapy in a breast cancer trial.

The randomized multicenter study ( Reposant sur des Arguments Pronostiques et Prédictifs [RAPP]-01 ) compared the effectiveness of 2 chemotherapy regimens.

The trial included 627 women aged 18-70 years, who had primary unilateral breast cancer and either a moderate number of positive axillary lymph nodes ( 3 or less ) or no positive axillary lymph nodes, but were at a high risk of relapse.
Patients were treated at 11 French cancer referral centers from June 1999 through January 2003.
Patients received Doxorubicin plus Docetaxel, or Doxorubicin plus Cyclophosphamide, given postoperatively for 4 courses.

The trial was terminated prematurely when 2 deaths related to drug toxicity and 1 case of bowel perforation with peritonitis occurred among patients with febrile neutropenia, all in the Doxorubicin-Docetaxel group.

The incidence of febrile neutropenia was significantly higher with the Doxorubicin-Docetaxel regimen ( 40.8 percent ) than with the Doxorubicin-Cyclophosphamide regimen ( 7.1 percent ).

The follow-up has been too short ( 24 months ) to analyze the primary end point, which was the disease-free survival rate at 5 years.

" The rate of toxic death has decreased far below 0.10 percent in more recent trials, " the authors write. " We observed a much higher rate of toxic death ( 0.63 percent ) with the Doxorubicin-Docetaxel regimen. The higher rate of febrile neutropenia observed with Doxorubicin-Docetaxel than with Doxorubicin-Cyclophosphamide in our trial may have induced severe immunosuppression and contributed to the high rate of toxic death, which was 3 times as much as that observed in [ another trial ], in which 3 of 7 deaths were attributable to sequential Docetaxel immunosuppression among 1,584 patients ( 0.19 percent )."

" This study shows that the Doxorubicin-Docetaxel combination is associated with an increased risk of severe sepsis and life-threatening complications. Clinicians should be aware of the potential toxicity of the Doxorubicin-Docetaxel regimen and consider the preventive use of Granulocyte Colony-Stimulating Factor ( G-CSF ) and/or antibiotics ( neither of which was recommended at the time of our trial) in both the adjuvant and metastatic settings. At this time the Doxorubicin-Docetaxel regimen should not be recommended outside of carefully designed clinical trials," the authors conclude.

Source: Journal of American Medical Association, 2005


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